DihexaAvailability: 295 in stock
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Availability: 295 in stock
Dihexa is a synthetic small-molecule peptide mimetic derived from the angiotensin IV (AngIV) peptide. It is specifically engineered to interact with the hepatocyte growth factor (HGF) / c-Met receptor system, a signaling pathway known to play a critical role in:
Neurogenesis
Synapse formation
Cognitive function
Long-term memory development
Unlike traditional peptides, Dihexa is orally bioavailable, highly stable, and able to cross the blood–brain barrier, making it one of the most potent experimental compounds studied for cognitive and neuroregenerative research.
Dihexa is strictly intended for laboratory and scientific research only and is not approved for human or veterinary use.
Dihexa is classified as a peptidomimetic small molecule, derived from an angiotensin IV backbone but chemically modified for enhanced potency and stability.
Key structural features include:
Molecular Formula: C₂₂H₃₀N₄O₃
Molecular Weight: ~398.5 g/mol
Structure Type: Angiotensin IV analog with cyclohexyl and acyl substitutions
Lipophilicity: High – allows efficient blood–brain barrier penetration
Enzymatic Stability: Highly resistant to proteolytic degradation
Unlike traditional peptides, Dihexa does not rapidly degrade in plasma, giving it a significantly longer functional activity window in preclinical models.
All effects listed below are based on preclinical laboratory and animal research only:
Dihexa strongly activates the HGF/c-Met signaling pathway, resulting in:
Rapid formation of new synaptic connections
Increased dendritic spine density
Enhanced neural network connectivity
This makes it one of the most powerful synaptogenic compounds ever studied in experimental neuroscience.
Animal studies show Dihexa supports:
Improved learning ability
Faster memory acquisition
Stronger memory retention
Recovery of cognitive function after neural injury
These effects are linked directly to increased synapse density rather than stimulant activity.
Research suggests Dihexa may assist in:
Neural repair after traumatic brain injury
Recovery from chemically induced cognitive damage
Support of neuronal survival
Its regenerative potential is tied to HGF-mediated neurotrophic signaling.
In advanced preclinical models, Dihexa has demonstrated:
Reversal of scopolamine-induced amnesia
Protection against beta-amyloid toxicity
Restoration of synaptic signaling in degenerative conditions
This positions Dihexa as a key experimental compound in Alzheimer’s disease research.
Dihexa
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2026-01-20
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JC
2026-01-16
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PV
2026-01-16
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DihexaAvailability: 295 in stock